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Concurrently, it activates caspase-3 expression and enzymatic activity, amplifying apoptotic execution in SK-MEL-28 and A375 cells (Manica et al., 2023)

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At the doses delivered through the compound formulation (5 to 30 mg per week), accumulation to toxic levels is extremely unlikely

Because of the non-vesicular nature of its release and spread as a gas, neuronal NO is generally released as a locally-active co-transmitter alongside whatever vesicular neurotransmitter(s) are released by a given neuron

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