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This extended duration of action is a key feature for researchers conducting long-term metabolic studies in animal models, allowing for sustained receptor engagement with less frequent administration

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For those with pre-DM, they are less likely to progress and more likely to revert to normoglycaemia

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Amantadine, bromocriptine, or phenterminetopiramate extended release should be encouraged in psychiatric patients, especially when presenting with extrapyramidal symptoms or elevated prolactin

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