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For most patients, GLP-1 medications are generally safe and well-tolerated, but like any medication, they can have side effects such as nausea, vomiting, diarrhea, or constipation

No other animals or data points were excluded from any of the in vivo study analyses

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By decreasing ROS production and inactivating the NF-B pathway, P4HB knockout inhibits the inflammatory responses of macrophages, including migration, M1 polarization, and secretion of TNF- and IL-6 [37]

[26] showed that liraglutide-dependent weight loss relies on its binding to GLP-1Rs located mainly in POMC/CART (cocaine- and amphetamine-regulated transcript) anorexigenic neurons in the ARC, but an indirect inhibitory effect of agouti-related peptide (AgRP) orexigenic neurons via -aminobutyric acid (GABA)-ergic signaling was also observed