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The triple-agonist mechanism (GLP-1 + GIP + glucagon) produces higher GI rates than semaglutide or tirzepatide alone, with the glucagon receptor being the primary driver of the difference

Tirzepatide is a GLP-1 agonist along with having a GIP agonist in there, which plays on our glucagon a bit

Extended gaps in dosing may require restarting the titration process, especially if you experience side effects when you resume

The result shows that GIPR-antibody can inhibit insulin secretion in B-hGIPR mice

For weight management, only semaglutide (Wegovy) and liraglutide (Saxenda) are specifically licensed in the UK

Side Effects and Contraindications While tirzepatide is a promising option for managing type 2 diabetes and aiding weight loss, its important to be aware of its potential side effects and contraindications