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This is one of the most important long-term risks of these medications and is directly addressed by intentional protein timing

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Weight loss associated with GLP-1 medications can include muscle mass loss if protein intake is insufficient

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In a Phase 2 trial, adults with obesity lost about 24% of their body weight after 48 weeks, the largest drop reported for this class so far

After adjustment of the model for weight loss, associations between the groups and headache outcomes did not remain statistically significant although a trend towards better headache outcomes in the GLP-1-RA group was noted