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Insulin resistance and metabolic dysfunctions frequently seen in PCOS have been linked to disruptions in calcium homeostasis

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Josimovich JB, Lavenhar MA, Devanesan MM, Sesta HJ, Wilchins SA, Smith AC

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These studies revealed that transmigrating neutrophils rapidly deplete the local environment of molecular oxygen and transcriptionally imprint the surrounding tissue to induce HIF target genes

Frontiers in endocrinology 5 , 241, (2014)