Empagliflozin in patients with heart failure, reduced ejection fraction, and volume overload: EMPEROR- Reduced Trial
Body Composition Changes After Bariatric Surgery or GLP-1RA
LDL cholesterol decreased by approximately 5-7 mg/dL, while HDL cholesterol showed modest increases
Fortunately, GLP1 medications are now FDA-indicated for multiple indications beyond weight management and diabetes, including: Major cardiovascular event (heart attack and/or stroke) risk reduction in adults with cardiovascular disease and overweight or obesity Metabolic dysfunctionassociated steatohepatitis (MASH) Moderate to severe obstructive sleep apnea (OSA) in adults with obesity When one medication can address multiple conditions, it simplifies care and reduces polypharmacy
However, it is not a replacement for traditional OSA therapies , such as: CPAP (Continuous Positive Airway Pressure) Oral appliances Since OSA severity does not always correlate directly with symptoms, documenting reductions in respiratory events is crucial before discontinuing conventional treatments
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