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Inhibition of EphA4 expression reduces the binding of Beclin1 and p-ERK1/2, significantly reduces the formation of Beclin1-xCT complex, and decreases the expression of c-Myc, TFR1 and p-ERK1/2, thereby largely preventing the ferroptosis of spinal dorsal horn neurons induced by SCIRI

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Currently, the proteins constituting the PANoptosome can be classified into three main categories: (1) PAMP or DAMP sensors, including ZBP1, AIM2, and NLRP3