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However, when the limit for storage of TAGs is reached or adipocyte lipolysis is dysregulated, FAs can accumulate in ectopic tissues such as skeletal muscle and the liver leading to insulin insensitivity and T2D (11)

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If the medication is stopped, appetite can return, and some patients regain a significant amount of weight

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Since EDS-related motility issues impact both structure and functioning of the MMC, SIBO for these clients often requires long-term management with prokinetics, dietary strategies, and periods of reducing the bacteria and archaea that may continuously overgrow