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This represents the largest mean weight loss reported for a weekly incretin-based drug in a phase 2 obesity trial
Commonly reported side effects for this medication class include nausea, vomiting, diarrhea, and constipation, along with more serious considerations such as pancreatitis risk, thyroid C-cell tumor boxed-warning language, and contraindications for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2
Subgroup, sensitivity and specificity analyses Subgroup analyses demonstrated that the benefit of GLP-1 RAs on overall survival, MACEs and MAKEs was broadly consistent across prespecified subgroups