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For first-time users, the published evidence base is strongest on topical at 1 to 2%

These side effects typically diminish over weeks and are manageable with proper nutrition and hydration

For anyone dealing with chronic low-grade inflammation which is essentially 99% of people past mid-adulthood this systemic effect may be more valuable than mere cosmetic improvements

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Observations in research suggest that significant changes in skin density, texture, and scar appearance can take 8-12 weeks or longer, consistent with the natural skin remodeling cycle

Chronic inflammation can result in long-term health imbalances