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(D) A schematic of the gene that is expressed in the Glp-1r / mice

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423,424 In addition, insulin and IGF1 inhibit sex-hormone binding globulin (SHBG) synthesis, although both hormones stimulate ovarian synthesis of sex steroids that can promote cellular proliferation and inhibit apoptosis in breast epithelium and endometrium

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Nat Rev Microbiol 18(3):15263