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Binding leads to a rotational change in the receptor transmembrane domain, which leads to transphosphorylation and activation of two JAK2 molecules that are associated with the cytoplasmic domain of the receptor

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Qi BW, Yulin Z, Xin W, Wenjing X, Hao Z, Zhizhi C, Xingmei D, Xia Z, Yuquan W, Lijuan C (2010) A further investigation concerning correlation between anti-fibrotic effect of liposomal Quercetin and inflammatory cytokines in pulmonary fibrosis

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