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Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements

Long-term systemic use is concerning for copper balance, as copper deficiency has been linked to neurodegenerative disorders and even excess copper is risky

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What do systematic reviews say

J Biol Chem 281:3451534524 [DOI] [PMC free article] [PubMed] [Google Scholar] Madia PA, Dighe SV, Sirohi S, Walker EA, Yoburn BC