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This high dose is used to quickly fill up the bodys stores

Tirzepatide liver-fat and body-composition MRI substudy SURPASS-3, relative liver-fat reduction -29.8/-39.6/-47.1% at 5/10/15 mg vs insulin degludec -11.2%: Gastaldelli Lancet D&E 2022

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Correcting B12 deficiency typically improves skin tone and color as red blood cell production normalizes and oxygenation improves

This might happen when you first start the medication or when your prescriber raises your dose

Many users find that metabolic benefits persist for several weeks after discontinuing treatment, suggesting lasting improvements in cellular function