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Zepbound's active molecule, tirzepatide, is a dual agonist
To investigate whether liraglutide-induced nausea requires the action of LS GLP-1R neurons, we used the standard conditioned taste avoidance (CTA) model (40) (Supplemental Figure 7P)
These can exacerbate potential nausea
Individually, the evidence base is strong
Example calculation: Target body weight: 175 lbs (80 kg) Current weight: 220 lbs (100 kg) Excess weight: 45 lbs (20 kg) Adjusted body weight: 80 + (0.25 20) = 85kg Daily protein target: 102170 grams These recommendations derive from weight loss research across multiple populations
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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