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Tirzepatide was shown to have 21% more weight loss than semaglutide 1.0mg in the SURPASS-2 trial in head-to-head studies

On the 12mg maintenance dose, participants lost an average of 28.7% of body weight versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)

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This triggers an increase in melanin, the pigment that gives skin its color and provides protection against UV radiation

Riboflavin (Vitamin B2): Helps convert fat into energy, enhancing the breakdown of fat deposits