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The TAA + Remo 25 mg/kg group demonstrated a substantial increase in SIRT1 immune-staining response and modest positivity of NF-kB p65 (Figure 8c)

[16] In a pooled analysis of 3 randomized trials, edema was reported in 4% of premenopausal women with metastatic breast cancer (MBC) who received tamoxifen therapy (n = 104)

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However, because it influences metabolic pathways, its essential to approach its use cautiously