Other common digestive side effects include: Vomiting: Often occurs alongside nausea, especially when starting treatment Diarrhea: Usually mild and temporary Constipation: Can occur as your digestive system adjusts Stomach pain: Typically mild and manageable Loss of appetite: While this contributes to weight loss, it can be concerning for some patients These digestive effects happen because GLP-1 slows how quickly food moves through your stomach
[DOI] [PubMed] [Google Scholar] 71.Wang M., Xu R., Liu X., Zhang L., Qiu S., Lu Y., Zhang P., Yan M., Zhu J
doi: 10.1152/physrev.00034.2006 2 Inflammation
Table of Contents How Retatrutide Affects Heart Rate Retatrutide increases resting heart rate primarily through GLP-1 receptor-mediated chronotropic effects at the sinoatrial node, potentially amplified by its glucagon receptor agonism, which independently raises heart rate and cardiac contractility
Early studies showed that people on GLP-1s lost quite a bit of lean mass, which some took to mean the loss of muscle
It can be taken at any time, without food or water restrictions, offering flexibility unmatched by other medications in its class