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Cortical spreading depression (CSD), characterized by a strong wave of neuronal depolarization accompanied by glial and vascular activation, is widely believed to underlie the aura phase of migraines (24)

Bttner, M., Miao, Z., Wolf, F

Tricyclic antidepressants (TCAs) independently slow gastric emptying and should not be combined with tirzepatide without close medical supervision due to compounded nausea risk

Hold the needle in place for about 5 to 10 seconds to allow the full dose to be delivered

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It will specifically assess whether tirzepatide reduces major adverse cardiovascular events (MACE) in people with type 2 diabetes and existing heart disease