Indeed, in obese mice it was seen that antibiotic-induced depletion of Bacillota and Bacteroidota alters the pool of intestinal metabolites, in particular by increasing taurocholic acid, which in turn stimulates the release of GLP-1 from L cells, improving glucose tolerance (19)
It works by mimicking a hormone called GLP-1 (glucagon-like peptide-1) that is naturally produced in the intestines
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Similar to global Glp1r/ mice, animals with deletion of the GLP-1R in vagal afferent/efferent nerves, Phox2b-Cre Glp1r flox/flox , as well as animals with a deletion of the GLP-1R in the CNS, nestin- Cre Glp1r flox/flox , maintain a similar body weight and food intake as control mice on both chow and HFD (Sisley et al., 2014)
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Research showed that oral glutathione in both forms is well tolerated and effectively influences skin properties