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When pups were tested for reproductive performance at maturation, gestational weight gain, number of implantations, and number of delivered pups were decreased in the group whose mothers had been given 10 mg/kg

- 11% higher risk of arthritis: this finding contradicts earlier studies suggesting weight loss from these drugs could alleviate joint pain

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75 Taken together, these mixed results suggest that GLP-1 receptor agonists still have a biological rationale for treating Parkinsons disease, but recent phase 3 trials have not yet delivered consistent evidence of disease modification

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