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doi: 10.1210/en.2018-00004

If fatigue significantly impairs quality of life despite these measures, alternative weight management strategies may need consideration

Hypoxia-induced senescence of PASMCs releases IL-6 via the mTOR/S6K1 pathway, and paracrine signals activate the metabolic-inflammatory network in adjacent cells, forming a metabolism-driven effect of senescence-associated secretory phenotype (Wang et al., 2021)

GE2 treatment increases neurogenesis in the dorsal hippocampus depending on sex and diet WD reduced the density of DCX-expressing cells compared to SD ( p = 0.024, Cohens d = 1.309), but only in males, and GE2 treatment normalized the density of DCX-expressing cells under a WD in males ( p = 0.008, Cohens d = 4.023