retatrutide ly3437943 glp-1 gip glucagon receptor agonist LY3437943, a novel triple glucagon, GIP, and for glycemic control and weight loss: From discovery to clinical proof of concept Retatrutide for Obesity: Phase 2

LibbatTzion Shaham, MD, contributed to this articles valuable insights

A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)

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10.1016/0014-4886(82)90047-4 Exp

This is not specific to tirzepatide or AOD 9604 but rather a consequence of rapid weight loss itself, known as telogen effluvium

Avoid sugar consumption: Limiting refined sugars intake helps protect collagen and elastin from damage, keeping the skin firmer and slowing premature aging