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Rizo-Tllez SA, Sekheri M, Filep JG

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AD-specific lactylation dysregulation centers on the glycolysis-H4K12la-PKM2 positive feedback loop in hippocampal microglia and tau lactylation in vulnerable neuronsthis dual-cell lactylation network directly promotes A phagocytosis impairment and tau pathological aggregation (Zhao and Xu, 2022), a mechanism not observed in ischemia-induced acute injury or PDs dopaminergic neuron-specific degeneration