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Some studies have reported that mood stabilizers, apart from altering glutamatergic neurotransmission, decrease intracellular pH, increase expression of the anti-apoptotic gene BCL-2 (by blocking the inhibition produced by histones), regulate expression of other genes, reduce elevated intracellular Ca 2+ and increase Ca 2+ storage capacity in the ER, and also induce mitochondrial migration to synaptic terminals, modulating neurotransmission (174, 215217)
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