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The obesity medications help overcome a biological mechanism that kicks in when people diet, triggering a coordinated effort by the body to prevent weight loss

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If you stop tirzepatide and wait two weeks (roughly four half-lives) before starting retatrutide, the previous medication will have largely cleared, and you are starting closer to baseline

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doi: 10.3201/eid1603.090290 110 LalA.PorterJ.SweetersN.NgV.EvansP.NeumayrL.et al

Generally, it should be kept at room temperature, away from light, heat, and moisture