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And yes, those medications work, and for some people they're absolutely the right move

In regulatory T cells, lactate is taken up by MCT1 and activates the nuclear translocation of NFAT (nuclear factor of activated T cells), thereby upregulating the expression of programmed cell death protein 1 (PD-1) and enhancing its immunosuppressive activity (84)

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Early retrospective studies in patients with IBD suggest improved clinical outcomes, such as reduced hospitalization and surgery rates, particularly in those with obesity

Proc Natl Acad Sci U S A 104: 19023-19028

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