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Alcohol offers empty calories, bloating, and, with GLP-1, a reduced dopamine reward: and is therefore often the first thing to be cut. The long term effect of GLP-1 consumption on alcohol is not yet known: but the direction of travel is clear.

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The study, which examined data from June 2020 to March 2023, assessed health outcomes for 30 obese patients (27 females, 3 males, average age 42) with varying stages of HS

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Example of a microdosing schedule: Weeks 1-4: 1.0 mg once weekly Weeks 5-8: 1.5 mg once weekly Weeks 9-12: 2.0 mg once weekly Week 13+: Transition to the standard 2.5 mg dose, then follow the standard escalation schedule

doi: 10.1136/bmjopen-2020-043054 384 StorrMStengelA