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doi: 10.3390/biom15040478 10 ArifA.ZahoorN.TangJ.TangM.DongL.KhanS
Pro-apoptotic elements, BCL2 associated X, apoptosis regulator (BAX) and BCL2 antagonist/killer 1 (BAK1), drive processes such as mitochondrial outer membrane permeabilization and the creation of the mitochondrial permeability transition pore (MPTP), thus regulating the formation of pores in the outer mitochondrial membrane [112]
Tissue distribution studies indicate preferential accumulation of schisandrin B and schisandrol B in hepatic and renal tissues (55, 56)
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