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Further, homozygous MTHFR 677TT appeared to be synergistic with heterozygous mutations of coagulation factors Factor V or prothrombin for the development of deep venous thrombosis or pulmonary embolisms

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Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3

doi: 10.3945/ajcn.113.065789 129 PoutonCWPorterCJ

3.3 Functional and mechanistic studies of phytochemical anti-inflammatory based on zebrafish models 3.3.1 Anti-inflammatory functions of phytochemical anti-inflammatory Zebrafish inflammation models have evolved into a multidimensional evaluation system encompassing whole-organism behavior, tissue-level pathology, and molecular mechanisms, thus providing a robust in vivo platform for systematic assessment of the anti-inflammatory efficacy of phytochemicals (Xie et al., 2020)

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