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T2DM is the most significant and extensively studied comorbidity in MASLD, as reviewed recently

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Excessive inflammatory cytokines can exacerbate damage to the heart and surrounding tissues, prolong recovery time, and even increase the risk of adverse events during the recovery phase

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To gain a metabolic overview of pancreatic islet cells treated with MOTS-c, we performed targeted metabolomics analysis on pancreatic islet cells, which were isolated from 60-week-old C57BL/6 littermate mice and ex vivo treated with MOTS-c and/or H 2 O 2