Common adverse effects include nausea, vomiting, diarrhoea, and constipation, which often improve over time
GLP-1 receptor agonists like semaglutide work by slowing stomach emptying and increasing fullness signals to the brain, but this same mechanism can trigger loose stools or diarrhea in some patients
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These agents mimic the action of glucagon-like peptide-1, stimulating insulin secretion, slowing gastric emptying, and promoting satiety