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Eltrombopag is an FDA-approved drug that was the first identified small-molecule TFEB inhibitor

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For example, in Glp1r Nes/ mice, semaglutide loses its acute antiinflammatory effects against LPS-induced inflammation, yet tirzepatide still effectively prevents TNF- induction, suggesting that tirzepatide does not rely exclusively on neuronal GLP-1R to exert this effect (22)

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Ruggenenti P, Perna A, Ganeva M, Ene-Iordache B, Remuzzi G

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