The shift in gut motility, combined with changes in bile acid absorption and fluid balance in the intestines, can lead to diarrhea, particularly during dose increases
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GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy
The co-therapy also improved glucose tolerance with comparable efficacy in WT and Vgat-Gipr KO mice relative to vehicle controls, albeit without superiority to acyl-GLP-1 (Fig