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NICE guidance specifies a maximum treatment duration of two years within the NHS

As a gastroenterologist, I regularly see patients who are unsure whether their nausea, bloating, or constipation while on these medications is normal or a sign of something more concerning

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You should always aim for the center of the rubber stopper

Who Should Exercise Caution With This Treatment Patients with pre-existing hypotension, established cardiovascular disease, chronic kidney disease, poorly controlled hypertension, or a history of pancreatitis or medullary thyroid carcinoma would require specialist oversight and careful riskbenefit assessment before any future use