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Cellular metabolism Cellular metabolism depends heavily on NAD+ to keep energy production efficient

Fruits like melons, apples, pears and berries and vegetables like broccoli, peppers and cauliflower are high in nutrients and antioxidants and low in calories and carbohydrates

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The mechanisms involve upregulating survival genes, reducing inflammatory mediators, activating vascular bypass pathways, and maintaining blood flow despite vessel occlusion

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Notably, key transcription factors such as SOX2, which promote and maintain the dry characteristics of cancer cells, can upregulate the expression and autocrine activity of IGF-2, and IGF-2 then activates the IGF-1R/AKT signaling pathway to enhance the invasive and stemness characteristics of bladder cancer, forming a vicious cycle (28)