It's incredibly disheartening
Hu T, Yuan X, Ye R, Zhou H, Lin J, Zhang C, Zhang H, Wei G, Dong M, Huang Y, Lim W, Liu Q, Lee HJ, Jin W (2017) Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat
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In some embodiments, the desired dose is conveniently presented in a single dose or as divided doses administered simultaneously (or over a short period of time) or at appropriate intervals