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Back in the summer of 1980, gastroenterologist Jean-Pierre Raufman started working at the National Institutes of Health

2026 Jan;69(1):3649

The higher the intracellular concentration of GSH, the better the protection against oxidative stress, disease progression, and ageing

However, when excess free Fe 2+ is present in the cell, ferritin is recruited and solubilized by specific cargo receptor recognition, and the released excess Fe 2+ in turn increases the formation of hydroxyl radicals through the Fenton reaction, inducing reactive oxygen species (ROS) production and increased susceptibility to cellular ferroptosis ( FIGURE 1 Lipid peroxidation is an important factor driving ferroptosis

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