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Metformin, an AMP-activated protein kinase (AMPK) activator widely used in diabetes, is currently in phase I clinical trials for heart failure with preserved ejection fraction (HFpEF) (Tables 1 and 2)

This shift was accompanied by increased lean mass in chow-fed male knockouts, suggesting a broader adaptation in body composition that may contribute to enhanced glucose utilization under non-stressed conditions

Factors influencing vitamin B6 status in domestic cats: age, disease, and body condition score