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This was investigated in a series of large pivotal trials conducted in patients with T2D without CVD, but these showed variable findings on the effect of intensive glucose lowering on the risk of macrovascular and microvascular complications and a causal relationship could not be established (

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The H 1 , H 2 and H 3 probes could be flexible enough to synergistically interact with the positively charged surface, enabling H 1 , H 2 and H 3 probes to be steadily assembled on the aminopropyl-modified cores, as core-H 1 H 2 H 3 probes