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2.5 Combination therapy inhibits the growth of Th- MYCN mouse NB spheroids To assess the antitumor potential of the dual and triple drug combinations in a more physiological model than cell lines, we used a 3D spheroid model of a transgenic mouse that overexpresses MYCN under the control of the tyrosine hydroxylase (Th) promoter

[PMC free article: PMC10708449] [PubMed: 38068819] 6

Reference-grade research compound

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Reconstitute or dissolve drugs for intravenous (IV), intramuscular (IM), or subcutaneous (SC) injection

Serious adverse events have not been widely reported, but this may reflect the relatively small number of people who have used the compound and the limited reporting mechanisms available