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By inhibiting NNMT, 5-Amino-1MQ has been shown to increase intracellular NAD+ and SAM availability, upregulate polyamine flux enzymes, and alter histone methylation patterns in preclinical adipocyte models

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Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation

10.1152/ajpgi.00168.2011 Am J Physiol Gastrointest Liver Physiol

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