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Some analysts, including William Blairs Andy Hsieh, believe injectable GLP-1s will remain dominant in high-income countries due to their higher potency

Due to species differences, dulaglutide (a human GLP-1 variant fused with a human IgG4 variant) showed a longer t 1/2 in humans than in monkeys (120 h versus 51.6 3.2 h, respectively) and further research will be required to determine whether Exendin-4-Fc also has a longer t 1/2 in humans

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Less Common but Serious Side Effects Rare but serious risks may include: Gallbladder problems Pancreatitis Severe dehydration Low blood sugar (when combined with other diabetes medications) Medical supervision significantly reduces these risks

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Modern societies have moved from famine to feast and obesity and its co-morbidities now sweep the world as a global epidemic