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First, a seemingly dramatic change in the unbound fraction from 1% to 10% releases less than 5% of the total amount of drug in the body into the unbound pool because less than one third of the drug in the body is bound to plasma proteins even in the most extreme cases, eg, warfarin

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Jarukamjorn et al

Unlike oral supplements, injections bypass the digestive system for faster and more efficient absorption

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The intestinal epithelial layer, therefore, plays an important role in limiting the translocation of bacterial molecular mimics of host components that could promote the development of ADs such as SLE (Fig