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With insulin resistance, common in people with excess adiposity, prediabetes, and type 2 diabetes, glucagon and insulin levels may be elevated

Nausea, vomiting, diarrhea, and constipation occur in 2050% of patients, though symptoms are typically mild to moderate and diminish over time

[PMC free article: PMC8565976] [PubMed: 34725113] 27

The stability of calcitonin levels provides strong evidence that GLP-1 receptor activation does not stimulate human C-cells

Nearly half the patients in the Naples study reported their headache days reduced by at least 50%

Most people who experience initial symptoms find they improve substantially by months 2-3