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Chronic administration of atypical antipsychotics including olanzapine [153, 154], aripiprazole, and clozapine [154] were reported to increase hippocampal neurogenesis, whereas haloperidol has no effect [155,156,157] or a negative one [154]

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The compound is described in the literature as pleiotropic: its downstream effects engage multiple biological systems simultaneously, and its primary binding receptor has not yet been identified

Clinical experience with semaglutide and tirzepatide shows weight typically returns after discontinuation, which supports long-term use

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