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5.2 Prospective clinical trial progress and results of tirzepatide in the treatment of type 2 diabetes with cardiovascular disease Currently, two significant cardiovascular outcome trials for tirzepatide are underway (or have recently concluded), including SURPASS-CVOT and SUMMIT
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According to available data in non-surgical patients, early treatment response (13 months) to the weight loss drug seems to be a good predictor of long-term weight maintenance [31,32,33,34]
Similarly, very low-calorie diets can trigger metabolic slowdown that paradoxically worsens weight loss resistance