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NAC supplementation has been studied for heavy metal detoxification, with some evidence of benefit for mercury and lead excretion, though clinical trials are limited [37]

Tubular epithelial fibroblast transdifferentiation (TEMT) has been proposed as a viable therapeutic option to decrease RF since it stimulates the expression of several fibro-cytokines, which represent a critical mechanism in the development of RF (Li et al., 2004

Glutathione during embryonic development

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