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Endogenous growth hormone is converted into IGF-1 to eliminate excess glucose, creating the chemical intrinsically

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Ahn J, Yoon MJ, Hong SH, Cha H, Lee D, Koo HS, Ko JE, Lee J, Oh S, Jeon NL, Kang YJ (2021) Three-dimensional microengineered vascularised endometrium-on-a-chip

This pharmacokinetic limitation poses a significant challenge for its therapeutic application, as only a small fraction of orally administered AC reaches systemic circulation, reducing its efficacy in vivo

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